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KMID : 0360419740100010041
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Korean Journal of Pharmacology
1974 Volume.10 No. 1 p.41 ~ p.45
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Effect of Ginseng Saponin on the Mobilization of Free Fatty Acid from Epididymal Fat Pad of Rat
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Abstract
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The effect of ginseng saponin on the release of free fatty acid from adipose tissue was studied in vitro.
1. The mobilization of free fatty acid from intact epididymal fat pad of rat, incubated in Krebs-Ringer bicarbonate buffer (pH 7.4) contained bovine serum albumin (4 w/v%), was increased by addition of ginseng sponin (1 mg/ml).
2. The mobilization of free fatty acid from homogenate of the epididymal fat pad of rat, of which hormone-sensitive lipese system was activated by pre-incubation of intact fat pad in the presence of epinephrine, was markedly increased by addition of ginseng saponin (0.1~l mg/ml).
3. It is considered that ginseng saponin potentiate the actions of epinephrine on hormone-sensitive lipase system of the adipose tissue of rat.
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